Nano-graphene oxide for cellular imaging and drug delivery

We develop functionalization chemistry in order to impart solubility and compatibility of nano-graphene oxide in biological environments

Xiaoming Sun

2008

Scholarcy highlights

  • The interesting physical properties of graphene, a novel one-atom-thick two-dimensional graphitic carbon system, have led to much excitement in recent years in material science and condensed-matter physics
  • polyethylene glycol onto the COOH groups, we obtained a product with high solubility and stability in salt and cellular solutions, which is desirable for biological applications
  • The ultra-small size of the nano-graphene oxide was caused by the sonication involved in both graphene oxide COOH synthesis and pegylation steps
  • We incubated B-cells imaged by detecting NIR photoluminescence in and T-cells in solutions of NGO PEG Rituxan the range 1100 to 2200 nm using a InGaAs detector conjugates at 4 °C to allow the conjugates to interact under 658 nm laser excitation
  • We found that ~40% of DOX loaded on NGO PEG
  • For DOX loaded onto NGO PEG Rituxan, we incubated the conjugates with Raji cells at 2 μmol/L
  • Cells were washed three times with PBS to remove unbound nano-graphene oxide polyethylene glycol before NIR photoluminescence imaging

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