Vasa vasorum imaging: A new window to the clinical detection of vulnerable atherosclerotic plaques

We present new information suggesting that microbubble contrast-enhanced Intravascular ultrasound can measure activity and inflammation within atherosclerotic plaques by imaging vasa vasorum density

Stéphane Carlier; Ioannis A. Kakadiaris; Nabil Dib; Manolis Vavuranakis; Sean M. O’Malley; Khawar Gul; Craig J. Hartley; Ralph Metcalfe; Roxana Mehran; Christodoulos Stefanadis; Erling Falk; Gregg Stone; Martin Leon; Morteza Naghavi

2007

Scholarcy highlights

  • Complications of vulnerable atherosclerotic plaques lead to heart attacks and strokes
  • It remains difficult to identify what plaques are vulnerable to these complications. Despite recent developments such as thermography, spectroscopy, and magnetic resonance imaging, none of them is approved for clinical use
  • Inability of Intravascular ultrasound in measuring plaque activity limits its value in detection of vulnerable plaques
  • We present new information suggesting that microbubble contrast-enhanced IVUS can measure activity and inflammation within atherosclerotic plaques by imaging vasa vasorum density
  • An increasing body of evidence indicates that vasa vasorum density may be a strong marker for plaque vulnerability
  • We suggest that a combination of structural assessment and vasa vasorum density imaging by IVUS can serve as the most powerful clinically available tool for characterization of vulnerable plaques
  • All Intravascular ultrasound images and movies are posted on the website of the Ultimate IVUS Collaborative Project: http://www.ultimateivus.com

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