Efficiency and bioavailability of new synthetic strigolactone mimics with potential for sustainable agronomical applications

Through a broad synthetic chemistry approach, we explored how structurally diverse SL derivatives could improve hyphal branching of Gigaspora spp Arbuscular mycorrhizal fungi under laboratory conditions and possibly boost mycorrhization into soil

Lorenzo Borghi; Claudio Screpanti; Alexandre Lumbroso; Mathilde Lachia; Christian G├╝beli; Alain De Mesmaeker

2021

Scholarcy highlights

  • Strigolactones are carotenoid derivatives synthetized in terrestrial plants and green algae
  • This study suggests that we could use a targeted, chemical-design approach to synthetize new SL derivatives to enable enhanced promotion of mycorrhization and potentially enhanced bioavailability compared to natural SLs
  • The results obtained with G. margarita followed a similar trend to G. rosea: SL4, SL15 and SL5 showed a strong and significant hyphal branching promotion effect compared to acetone other compounds
  • Modification of the canonical D-ring of N-H strigolactam by introduction of an additional methoxy group at the C3 carbon of the butenolide ring in SL7 increased, albeit not significantly its hyphal branching induction activity compared to the unsubstituted strigolactams SL5 and SL7, which was not the case for the corresponding lactones where the additional methyl group had a significant detrimental effect in SL12 being inactive compared to GR-24
  • The improved, albeit not significant biological performance of the methoxy-substituted D-ring derivatives SL15 might partially arise from a stabilization of the sensitive D-ring towards hydrolysis by to the electron-donating ability of these substituents. These results demonstrate that the N-H strigolactam motive could be effectively modified in several positions of the tetracyclic core structure to reach promising hyphal branching induction activity, retaining the favorable physicochemical properties compared to their lactone analogs
  • Efforts in optimizing highperforming Arbuscular mycorrhizal fungi strains coupled with synthetic SL signals represent a new technological venue towards sustainable agriculture

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