The developmental origins of sarcopenia

We reviewed the published evidence for an association between lower birth weight and reduced grip strength in later life and derived a pooled estimate for the effect of birth weight on grip strength in absolute terms

A. A. Sayer

2008

Scholarcy highlights

  • Sarcopenia is defined as the loss of skeletal muscle mass and strength with age
  • To date most observational and interventional epidemiological studies have focused on factors modifying decline in later life but this life course model of sarcopenia focuses attention on the determinants of peak muscle mass and strength attained in early adulthood
  • Lower birth weight and weight at one year were significantly associated with lower grip strength in later life
  • Results of the review—Ten independent articles described the relationship between birth weight and grip strength in later life
  • For example grip strength increased by 2.42 kg per kilogram of birth weight in men aged 59 - 71 years taking part in the Hertfordshire Cohort Study
  • A more recent study focused on a group of 20 young men and showed altered skeletal muscle fibre composition and size in those with low birth weight

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