Succinate accumulation in man during exercise

It has been demonstrated in several diving vertebrates that succinate, a component of the Krebs cycle, accumulates in blood during breath-hold dives

Peter W. Hochachka; Rudolph H. Dressendorfer

2004

Scholarcy highlights

  • It has been demonstrated in several diving vertebrates that succinate, a component of the Krebs cycle, accumulates in blood during breath-hold dives
  • The production of succinate is thought to result from amino acid catabolism
  • Our purpose was to determine whether succinate accumulation occurs in man during muscular activity requiring anaerobic energy contribution
  • During 1 min breath-hold “dives” in cold water while exercising at a work rate equivalent to 62% of \(\dot V\)O2max, venous succinate increased from 42 Μmoles/l at rest to 125 M×10−6
  • It was suggested that amino acid catabolism may provide a source of anaerobic energy production in addition to glycolysis
  • Acta 216, 54–62 Hochachka, P.W., Dressendorfer, R.H. Succinate accumulation in man during exercise

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