These results suggested that gold compounds have an antiangiogenic effect in vivo
2004
Key concepts
Scholarcy highlights
- As mononuclear cell infiltration and growth of pannus critically depend on synovial neovascularization in rheumatoid arthritis, inhibition of the synovial blood vessels would have the potential to reduce rheumatoid inflammation
- We studied the effect of gold sodium thiomalate and auranofin on neovascularization in vivo by using a micropocket technique
- No inhibition was observed when non-steroidal anti-inflammatory drugs were injected intravenously on a daily basis. These results suggested that gold compounds have an antiangiogenic effect in vivo
- The inhibition of neovascularization by gold compounds suggested that they may suppress rheumatoid synovitis by reducing the number of small blood vessels required for mononuclear cell infiltration and synovial tissue proliferation
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