Possibilities of Targeted Therapies for Brain Metastasis

In the era of therapies successfully targeting distinct molecular pathways in cancer, the incidence and relevance of brain metastases are rising

Frank Winkler

2013

Scholarcy highlights

  • In the era of therapies successfully targeting distinct molecular pathways in cancer, the incidence and relevance of brain metastases are rising
  • Local approaches inevitably fail to address the multifocal nature of the disease, whole brain radiotherapy shows relevant neurotoxicity, and systemic chemotherapy faces the obstacle of the blood-brain/tumor-barrier
  • Judicious addition of targeted agents to the therapeutic armamentarium for brain metastases holds the promise to make a real difference for patients suffering from this devastating disease
  • Because of their unfavorable prognosis, patients with brain metastases have traditionally been excluded from studies with targeted therapies
  • The following chapter gives an overview of new therapies targeting molecular pathways both in the tumor stroma and in cancer cells, covering its theoretical and reported activity against brain metastases
  • A special emphasis will be placed on prophylaxis, i.e. prevention of macrometastasis formation

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