An Overview of Antimicrobial Properties of Different Classes of Phytochemicals

This paper presents the antimicrobial properties of some major group of phytochemicals against pathogenic bacteria, fungi and virus, and beneficial microbes of the gastrointestinal tracts and their mechanism of action

Amlan Kumar Patra

2012

Scholarcy highlights

  • Plants contain a wide array of phytochemicals, which have traditionally been utilized for centuries in folk medicines or ethnomedicines
  • This paper presents the antimicrobial properties of some major group of phytochemicals against pathogenic bacteria, fungi and virus, and beneficial microbes of the gastrointestinal tracts and their mechanism of action
  • There are some encouraging effects in vivo to inhibit pathogenic microbes without affecting beneficial bacteria in the gastrointestinal tracts, more studies would be required for the safety and efficacy of these phytochemicals to establish whether they could offer therapeutic benefits over conventional therapies
  • The combination of some antimicrobial drugs and phytochemicals may act as better antimicrobial agents than antimicrobial drugs alone
  • The application of dual combinations demonstrated synergy between streptomycin and gallic acid, ferulic acid, chlorogenic acid, allylisothiocyanate and 2-phenyle¬≠thyliso¬≠thiocyanate against the Gram-negative bacteria. They can act synergistically with less efficient antibiotics to control bacterial growth. 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid increased the susceptibility of S. enterica subsp. enterica serovar Typhimurium strains for novobiocin
  • The content of S-alk(en)yl-L-cysteine sulphoxides in garlic may range from 0.53% to 1.3% of fresh weight with S-allyl-L-cysteine sulphoxide being the largest contributor
  • Allicin has a synergistic effect with amphotericin B against C. albicans via enhancing the phospholipid peroxidation reaction in vitro and in vivo, which suggests that allicin could reduce the amphotericin B dose to lessen side effects
  • All these evidence suggest that intake of phytochemicals rich foods could be considered in future research while antimicrobial agents are applied to the body

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