Asbestos exposure causes multiple nonmalignant and malignant diseases through complex mechanisms that are not fully understood
2014
Key concepts
Scholarcy highlights
- Asbestos exposure causes multiple nonmalignant and malignant diseases through complex mechanisms that are not fully understood
- Oxidant generation is strongly implicated in the pathogenesis of asbestos-related diseases by evidence from various in vitro and in vivo studies
- We will describe how asbestos-induced oxidants influence multiple downstream biological processes involved in DNA damage, apoptosis, mitogen-activated protein kinase signaling, and inflammation
- Work by our group is supported by RO1 ES021110 and T32 ES007122 from NIEHS and a grant from Mesothelioma Applied Research Foundation
- Robinson C, Woo S et al The antioxidants vitamins A and E and selenium do not reduce the incidence of asbestos-induced disease in a mouse model of mesothelioma
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