Asbestos-Induced Oxidative Stress in Lung Pathogenesis

Asbestos exposure causes multiple nonmalignant and malignant diseases through complex mechanisms that are not fully understood

Jill Miller; Joyce Thompson; Arti Shukla

2014

Scholarcy highlights

  • Asbestos exposure causes multiple nonmalignant and malignant diseases through complex mechanisms that are not fully understood
  • Oxidant generation is strongly implicated in the pathogenesis of asbestos-related diseases by evidence from various in vitro and in vivo studies
  • We will describe how asbestos-induced oxidants influence multiple downstream biological processes involved in DNA damage, apoptosis, mitogen-activated protein kinase signaling, and inflammation
  • Work by our group is supported by RO1 ES021110 and T32 ES007122 from NIEHS and a grant from Mesothelioma Applied Research Foundation
  • Robinson C, Woo S et al The antioxidants vitamins A and E and selenium do not reduce the incidence of asbestos-induced disease in a mouse model of mesothelioma

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