Free Radicals in Aging – An Evolutionary Perspective

We provide an overview of recent studies using novel animal models of successful aging, which have provided valuable additional information to support or counter the oxidative stress hypothesis of aging

Anna Csiszar

2014

Scholarcy highlights

  • Evidence supporting the role of oxidative stress in the aging process is presented in detail in this chapter
  • We provide an overview of recent studies using novel animal models of successful aging, which have provided valuable additional information to support or counter the oxidative stress hypothesis of aging
  • We focus on comparative studies using three long-lived but mouse-sized mammalian species, the naked mole rat, the white-footed mouse, and the little brown bat, cells of long-lived and short-lived primates, and bivalve models of exceptional longevity to test predictions of the oxidative stress theory of aging
  • It is concluded that studies examining cellular and mitochondrial free radical generation and oxidative stress resistance in a broad array of successfully aging species seem to concur in general with predictions based upon the oxidative stress theory of aging
  • Further studies are needed to investigate mechanisms related to ROS homeostasis, protein recycling, and DNA repair that might be informative about successful aging of these species

Need more features? Save interactive summary cards to your Scholarcy Library.