Sucrose and Trehalose in Therapeutic Protein Formulations

Sucrose and trehalose are key ingredients in the formulation and stabilization of biotherapeutics. Their utility and function is driven by their unique chemical and physical properties, especially in aqueous solutions which are summarized in this chapter

Satish K. Singh

2018

Scholarcy highlights

  • Sucrose and trehalose are key ingredients in the formulation and stabilization of biotherapeutics. Their utility and function is driven by their unique chemical and physical properties, especially in aqueous solutions which are summarized in this chapter
  • There are commonalities as well as differences in these properties that arise from their conformation, H-bonding characteristics, water-binding ability, glass transition temperatures, polymorphic behavior, solubility, chemical stability etc
  • Compendial monographs are available for both sugars, and the safety and tolerability have been well documented
  • The final assessment is dependent on the individual biotherapeutic, experience suggests that sucrose can generally be considered as suitable in most cases, unless constrained by a low-pH formulation

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