Lessons from Knowledge on the Correlates of the Age of Onset of Physical Illness

We present different models of the environmental influences on disease risk, including the theory of “epigenetic memory in response to environmental stressors”, which has been proposed to describe the biological mechanisms linking exogenous and endogenous exposures to disease risk factors, DNA methylation dysregulation and ageing

Giovanni Fiorito

2018

Scholarcy highlights

  • Epidemiological studies over the last century have highlighted that the risk of non-communicable diseases increases with age, and suggest that ageing can be considered a marker of the accumulation of exposure to modifiable risk factors
  • We present different models of the environmental influences on disease risk, including the theory of “epigenetic memory in response to environmental stressors”, which has been proposed to describe the biological mechanisms linking exogenous and endogenous exposures to disease risk factors, DNA methylation dysregulation and ageing
  • The concepts of “epigenetic clock”, “epigenetic drift” and epigenetic age acceleration are discussed

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