Sensing Environmental Factors: The Emerging Role of Receptors in Epidermal Homeostasis and Whole-Body Health

These results suggest that the epidermis plays an important role in adapting whole-body physiology, and probably emotional response, to changing environments

Mitsuhiro Denda

2016

Scholarcy highlights

  • Epidermal keratinocytes have been recognized to form the water-impermeable structure and this barrier function is critical, especially for terrestrial animals
  • Recent findings have dramatically changed the picture of epidermal keratinocytes, placing them at the forefront of the sensory system
  • Keratinocytes contains environmental sensors and a sensory information-processing system, and it generates a variety of hormones and neurotransmitters that influence whole-body states and emotions
  • All the components of the hypothalamo-pituitary-adrenal axis appear to be present in epidermal keratinocytes. These results suggest that the epidermis plays an important role in adapting whole-body physiology, and probably emotional response, to changing environments

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