Pathophysiology of Atopic Dermatitis/Eczema

Atopic diseases are strongly genetically influenced. This is evident from twin studies where monozygous twins show a concordance of 80 % of atopic eczema while dizygous twins only show ca. 20 %

Johannes Ring

2016

Scholarcy highlights

  • Atopic diseases are strongly genetically influenced. This is evident from twin studies where monozygous twins show a concordance of 80 % of atopic eczema while dizygous twins only show ca. 20 %
  • The risk to develop atopic eczema is 40 % for children with one atopic parent. When both parents are affected by the same manifestation of atopy, the risk is between 70 and 80 %
  • Similar high concordance rates can be found for extrinsic and intrinsic atopic dermatitis

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