Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection

These results suggest that Monoamine oxidase may be involved in the cell death process initiated in mitochondria

M. Naoi

2006

Scholarcy highlights

  • In neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases, apoptosis is a common type of cell death, and mitochondria emerge as the major organelle to initiate death cascade
  • Monoamine oxidase in the mitochondrial outer membrane produces hydrogen peroxide by oxidation of monoamine substrates, and induces oxidative stress resulting in neuronal degeneration
  • A series of inhibitors of type B MAO protect neurons from cell death. These results suggest that MAO may be involved in the cell death process initiated in mitochondria
  • We present our recent results on the role of MAO in activating and regulating cell death processing in mitochondria
  • These results demonstrate a novel function of MAO-A in the induction and regulation of apoptosis
  • Youdim MBH, Maruyama W, Naoi M Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective Monoamine oxidase-B inhibitor antiparkinsonian drug, rasagiline

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