Mitochondria, free radicals, neurodegeneration and aging

The discovery that defects of the mitochondrial respiratory chain can result in human diseases is relatively recent

A. H. V. Schapira

2012

Scholarcy highlights

  • The discovery that defects of the mitochondrial respiratory chain can result in human diseases is relatively recent
  • Over the same period evidence has been presented which suggests that mutations of mitochondrial DNA and a decline in respiratory chain function contribute to the aging process
  • This chapter will review the lessons that can be learned from our study of inborn metabolic defects of the respiratory chain in understanding the functional importance of cumulative mitochondrial DNA mutations
  • The potential role of mitochondrial toxins in human disease will be discussed

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