Plant Natural Products for Mitigation of Antibiotic Resistance

We have summarised recent findings on five groups of plant natural products, namely flavonoids, phenolic acids, peptides, essential oils, and honey, as antibacterial agents

Wen-Jie Ng; Chong-Seng Shit; Kah-Yaw Ee; Tsun-Thai Chai

2021

Scholarcy highlights

  • The emergence of antibiotic resistance and in particular multi drug resistance is of great threat to human health worldwide
  • Amid the ongoing efforts to search for novel antibacterial agents as alternatives to conventional antibiotics, researchers have intensively explored the potency of various antibacterial compounds derived from plant sources
  • We have summarised recent findings on five groups of plant natural products, namely flavonoids, phenolic acids, peptides, essential oils, and honey, as antibacterial agents
  • Research to date has demonstrated their effectiveness in combating various bacterial pathogens, including antibiotic resistant strains
  • These natural products exert their inhibitory effects through diverse mechanisms, for instance, perturbation of bacterial membrane integrity, inhibition of intracellular metabolism, in addition to interfering with quorum sensing and biofilm formation
  • Flavonoids and phenolic acids with superior inhibitory effects against human pathogenic bacteria, including relatively detailed understanding of their modes of action, have been documented

Need more features? Save interactive summary cards to your Scholarcy Library.