Tumor plasticity drives adaptive response of cancer cells to hypoxia and nutrient deprivation leading to stimulation of neoangionesis or tumor escape
2020
Key concepts
Scholarcy highlights
- Tumor plasticity drives adaptive response of cancer cells to hypoxia and nutrient deprivation leading to stimulation of neoangionesis or tumor escape
- Tumor plasticity is believed to be a great contributor in recurrence and metastatic dissemination of cancer cells
- The reactivation of stem-like signalling pathways is considered a great determinant of tumor plasticity; in addition, a key role has been attributed to tumor microenvironment
- It has been proved that cancer cells interact with different cells in the surrounding extracellular matrix
- Well-established communication represents a potential allied in maintenance of a plastic phenotype in cancer cells supporting tumor growth and spread
- An important signalling pathway mediating cancer cell-tumor microenvironment crosstalk is represented by the HGF/c-Met signalling
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