HGF/c-Met Signalling in the Tumor Microenvironment

Tumor plasticity drives adaptive response of cancer cells to hypoxia and nutrient deprivation leading to stimulation of neoangionesis or tumor escape

Alberto Zambelli; Giuseppe Biamonti; Angela Amato

2020

Scholarcy highlights

  • Tumor plasticity drives adaptive response of cancer cells to hypoxia and nutrient deprivation leading to stimulation of neoangionesis or tumor escape
  • Tumor plasticity is believed to be a great contributor in recurrence and metastatic dissemination of cancer cells
  • The reactivation of stem-like signalling pathways is considered a great determinant of tumor plasticity; in addition, a key role has been attributed to tumor microenvironment
  • It has been proved that cancer cells interact with different cells in the surrounding extracellular matrix
  • Well-established communication represents a potential allied in maintenance of a plastic phenotype in cancer cells supporting tumor growth and spread
  • An important signalling pathway mediating cancer cell-tumor microenvironment crosstalk is represented by the HGF/c-Met signalling

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