Hydrogen Peroxide (H2O2)- and Nitric Oxide (NO)-Derived Posttranslational Modifications

Redox reactions, which are a very old signaling phenomenon in evolutionarily terms, occur in prokaryotes and eukaryotes

R. Valderrama

2019

Scholarcy highlights

  • Redox reactions, which are a very old signaling phenomenon in evolutionarily terms, occur in prokaryotes and eukaryotes
  • Posttranslational modifications of proteins can be considered an additional step in protein metabolism that greatly expands the proteome of living organisms
  • PTMs affect protein structure and activity which are associated with concomitant changes in signaling and gene expression that make cellular systems more dynamic
  • H2O2 and nitric oxide are essential signaling molecules involved in many physiological processes and plant responses to unfavorable conditions
  • These diverse functions can be partly explained by the fact that reactive oxygen species and NO rapidly interact to form a number of reactive nitrogen species, such as peroxynitrite, nitrogen dioxide, dinitrogen trioxide, and other NOx species
  • As these molecules share signaling pathways, it is not surprising that cross talk enables pathways to control each other’s functions

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