Chitosan: A Biocompatible Material for Oral and Intravenous Administrations

Chitosan is the N-deacetylated product of chitin {(1→4)-linked 2-acetamido-2-deoxy-β-D-glucan}, which is abundant in nature

Shigehiro Hirano

2013

Key concepts

Scholarcy highlights

  • Chitosan is the N-deacetylated product of chitin {(1→4)-linked 2-acetamido-2-deoxy-β-D-glucan}, which is abundant in nature
  • (1) No abnormal symptom was observed with several animals when chitosan was orally administered at a dosage of 0.7–0.8 g/kg body weight/day for up to 239 days
  • (3) No abnormal symptom was observed with rabbits when low-molecular-weight-chitosan or chitosan oligosaccharides were injected intravenously at a dosage of 4.5 mg/kg body weight/day for 7–11 days
  • (4) Hypocholesterolemic function was observed with chitosan administered orally but not with LMW-chitosan or oligosaccharides injected intravenously. These data strongly indicate that chitosan is usable as a novel carrier of drugs in the drug delivery system for oral and intravenous administration

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