Activation of Transcription by the Cyclic AMP Receptor Protein

Musso, R., DiLauro, R., Adhya, S., and de Crombrugghe, B., 1977, Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interdispersed promoters, Cell12: 847.PubMedCrossRefGoogle Scholar

Benoit De Crombrugghe

2013

Scholarcy highlights

  • Musso, R., DiLauro, R., Adhya, S., and de Crombrugghe, B., 1977, Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interdispersed promoters, Cell12: 847.PubMedCrossRefGoogle Scholar
  • In bacteria the effects of Cyclic AMP are mediated by the cAMP receptor protein
  • Our aim in this article is to address the question: How does CRP activate transcription in bacterial cells? A detailed examination of the mode of action of CRP should help us understand better the mechanisms which govern the activation of genes in prokaryotes, and may provide a conceptual framework in discussions on the role of activators of transcription in eukaryotes

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