Assay Systems: Testing of Antiviral Drugs in Cell Culture (In Vitro)

Testing for virus-inhibitory activity of chemicals in cell culture has sometimes furnished important leads in the development of antiviral drugs. The shortcomings of this so-called in vitro testing are obvious: substances which lack an effect on the viral replication cycle but, e.g., enhance antibody formation, improve nonspecific resistance, strengthen the interferon systems will not be detected by this method

Hans J. Eggers

2012

Scholarcy highlights

  • Testing for virus-inhibitory activity of chemicals in cell culture has sometimes furnished important leads in the development of antiviral drugs. The shortcomings of this so-called in vitro testing are obvious: substances which lack an effect on the viral replication cycle but, e.g., enhance antibody formation, improve nonspecific resistance, strengthen the interferon systems will not be detected by this method
  • The reverse is true, viz. more compounds do appear active in a cell culture system than will later be found useful in the organism
  • I shall refer to this problem in a later section

Need more features? Save interactive summary cards to your Scholarcy Library.