Structure, Function, and Antigenicity of the Hemagglutinin of Influenza Virus

The major surface glycoprotein of influenza virus is hemagglutinin.

S. A. Wharton

2011

Key concepts

Scholarcy highlights

  • The major surface glycoprotein of influenza virus is hemagglutinin.
  • This chapter reviews the two major functions of HA: its involvement in binding to receptors on cells before their infection, and its role in the fusion of viral and endosomal membranes, necessary for the release of the viral genome into the cell.
  • HA is the viral antigen that interacts with infectivity-neutralizing antibodies; alterations in the molecule enable the virus to escape immune surveillance and cause epidemics of disease.
  • The nature of these changes in antigenicity is discussed.

Need more features? Save interactive summary cards to your Scholarcy Library.