Vascularization of the Placenta

The development of a functional vascular network involves vasculogenesis and angiogenesis

Ronald J. Torry; Joanna Schwartz; Donald S. Torry

2011

Scholarcy highlights

  • The development of a functional vascular network involves vasculogenesis and angiogenesis
  • There have been intensive efforts to determine the molecular mechanisms regulating vascular growth and development, and much of the rationale for this has stemmed from the increasing clinical importance and therapeutic potential of modulating angiogenesis during various disease states
  • Significant angiogenesis in the adult is generally limited to pathologic conditions such as arthritis, retinopathy, chronic inflammation, wound healing, and solid tumor growth
  • The female reproductive tract of primates undergoes substantial vascular growth and remodeling associated with the menstrual cycle and pregnancy
  • Embryonic death of Mekl-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
  • On the factors which contribute to thinning of the villous membrane in human placentae at high altitude
  • An increase in the degree of peripheralization of fetal capillaries

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