The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation

Thomas Willis noted in his Cerebri Anatome that brain vessels were accompanied by fibers

R. Macfarlane

2011

Scholarcy highlights

  • Thomas Willis noted in his Cerebri Anatome that brain vessels were accompanied by fibers
  • Levine and Wolff demonstrated that electrical stimulation of cat pial arteries increased galvanic skin responses, and that this effect was blocked by the application of procaine to the vessel
  • Wall and Pribram found that the hypertensive response to electrical stimulation of pial arteries was blocked by trigeminal neurotomy
  • It was not until the axonal tracing studies of Mayberg and colleagues that direct connections between the trigeminal nerve and the circle of Willis were documented

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