In this chapter we summarise the current knowledge of cellular quality control systems with special emphasis on the role of the mitochondrial protein quality control system and its impact on biological aging and disease
2011
Key concepts
Scholarcy highlights
- Preserving the integrity of proteins, biomolecules prone to molecular damage, is a fundamental function of all biological systems
- Cells contain a hierarchical system of pathways coping protein damage
- Mitochondrial proteins are under high risk to become damaged
- The mitochondrial protein quality control system consists of chaperones that counteract protein aggregation through binding and refolding misfolded polypeptides and of membrane-bound and soluble ATP-dependent proteases that are involved in degradation of damaged proteins
- In this chapter we summarise the current knowledge of cellular quality control systems with special emphasis on the role of the mitochondrial PQC system and its impact on biological aging and disease
- Tzagoloff A, Yue J, Jang J et al A new member of a family of ATPases is essential for assembly of mitochondrial respiratory chain and ATP synthetase complexes in Saccharomyces cerevisiae
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