Imaging the Nanoscale Distribution of Phosphoinositides in the Cell Plasma Membrane with Single-Molecule Localization Super-Resolution Microscopy

We describe a single-molecule method to visualize the nanoscale distribution of PtdIns(4,5)P2 in the plasma membrane by using super-resolution microscopy and the dual-color fluorescent probes based on the PLCĪ“1 pleckstrin homology domain

Fan Fan; Chen Ji; Xuelin Lou


Scholarcy highlights

  • Phosphoinositides make up only a small fraction of cellular phospholipids yet control cell function in a fundamental manner
  • This approach can be extended to image other phosphoinositides by changing the specific probes

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