Regulation of SNARE Complex Assembly by Second Messengers

Many specialized cell types are dedicated to the regulated exocytosis of biologically active substances

Alexander J. A. Groffen

2008

Scholarcy highlights

  • Many specialized cell types are dedicated to the regulated exocytosis of biologically active substances
  • The secretory cargo is stored in vesicles, that have a low release probability in the absence of suitable secretory signals
  • Membrane fusion requires the assembly of soluble N-ethylmaleimide attachment protein receptor proteins into a trimeric SNARE complex, in mammals composed of syntaxin, SNAP-25/23 and synaptobrevin
  • SNARE complex assembly is sufficient to drive fusion of liposomes in cell-free systems, 2,3 spatially and temporally controlled membrane fusion in living cells requires the activity of accessory proteins
  • Such accessory proteins have been identified, for instance Muncl and Muncl, that are essential for regulated secretion

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