Inflammatory Activity in Autism Spectrum Disorder

We addressed the hypothesis that inflammatory activity might be enhanced in children suffering from Autism spectrum disorder

I. Tonhajzerova; I. Ondrejka; M. Mestanik; P. Mikolka; I. Hrtanek; A. Mestanikova; I. Bujnakova; D. Mokra

2015

Scholarcy highlights

  • Autism spectrum disorder is a severe neurodevelopmental disorder in early childhood characterized by impairment in communication and behavior
  • Recent research is focused on the immune dysregulation as a potential pathomechanism leading to ASD
  • We addressed the hypothesis that inflammatory activity might be enhanced in children suffering from ASD
  • We examined 15 children with ASD and 20 age/gender-matched healthy subjects as a control group
  • We found that the level of interleukin 8 was significantly increased in the ASD children, whereas the other markers remained unappreciably changed compared to controls
  • The study demonstrates a discrete immune dysfunction in Autism spectrum disorder of pro-inflammatory character

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