Botulinum Neurotoxins: Mechanism of Action

This review reports the progress on our understanding of how Botulinum neurotoxins cause nerve paralysis highlighting the different steps of their molecular mechanism of action as key aspects to explain their extreme toxicity and their unique pharmacological properties

O. Rossetto; M. Pirazzini; F. Fabris; C. Montecucco

2020

Scholarcy highlights

  • Botulinum neurotoxins are a growing family of bacterial protein toxins that cause botulism, a rare but often fatal animal and human disease
  • The specificity and rapidity of binding, which limits the anatomical area of its neuroparalytic action, and its reversible action make BoNT a valuable pharmaceutical to treat neurological and non-neurological diseases determined by hyperactivity of cholinergic nerve terminals
  • This review reports the progress on our understanding of how BoNTs cause nerve paralysis highlighting the different steps of their molecular mechanism of action as key aspects to explain their extreme toxicity and their unique pharmacological properties
  • Rossetto O, Pirazzini M, Lista F, Montecucco C The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs

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