Endocrine Disruption and In Vitro Ecotoxicology: Recent Advances and Approaches

We examine the battery of in vitro bioassays currently in use in ecotoxicological research and discuss the following key questions

Martin Wagner; Cornelia Kienle; Etiënne L. M. Vermeirssen; Jörg Oehlmann

2017

Scholarcy highlights

  • Endocrine-disrupting chemicals are man-made compounds interfering with hormone signaling
  • BPA found to be estrogenic in the 1930s 370 but was abandoned as synthetic estrogen in favor of the more potent diethylstilbestrol
  • Given the almost universal contamination of freshwater ecosystems with wastewater, the issue of feminization became the focal point for research on ED in fish and EDCs in wastewater
  • Only produced by mature females, its prevalence in juvenile or male fish is considered a biomarker of exposure to estrogenic substances
  • Similar effects have been observed in pearl dace
  • Similar effects can be induced by other endocrine disruptors, including 17β-estradiol, atrazine, and Bisphenol A 379
  • Because the induction/repression of the receptor-mediated gene expression is studied, the organizational level under investigation is transcription

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