Signal Amplification Techniques: bDNA, Hybrid Capture

Several molecular technologies are designed to avoid target amplification so to minimize the possibility of contamination by target amplification products

Yun F. (Wayne) Wang

2007

Scholarcy highlights

  • Several molecular technologies are designed to avoid target amplification so to minimize the possibility of contamination by target amplification products
  • One of the alternatives to enzymatic amplification of target nucleic acid such as polymerase chain reaction is to increase or amplify the signal generated from the probe molecule hybridized to the target nucleic acid sequence, which is referred to as signal amplification
  • The branched DNA method was initially developed by Chiron and marketed by Bayer Diagnostics, and the hybrid capture method was developed and marketed by Digene Corporation

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