Neoplastic disease follows the acquisition of mutations within genes, a process that may span many years
2006
Key concepts
Scholarcy highlights
- Neoplastic disease follows the acquisition of mutations within genes, a process that may span many years
- When these mutations occur in proto-oncogenes that normally encode for proteins which control the cell cycle, DNA repair and transcriptional events, the result is deregulation of cellular proliferation and other intracellular pathways, leading to tumour development
- The identification of the major excreted protein from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L
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