Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease

The ϵ4 allele of apolipoprotein E is a risk factor for Alzheimer's disease, perhaps through effects on amyloid-β metabolism

Anne M. Fagan; Melanie Watson; Maia Parsadanian; Kelly R. Bales; Steven M. Paul; David M. Holtzman

2002

Scholarcy highlights

  • The ϵ4 allele of apolipoprotein E is a risk factor for Alzheimer's disease, perhaps through effects on amyloid-β metabolism
  • Isoform-specific effects of human apolipoprotein E on Aβ levels and neuritic plaque formation mimicked that observed in AD
  • Observation of an apoE-dependent decrease in percent soluble Aβ and enrichment of Aβ in membrane microdomains prior to Aβ deposition indicates that apoE influences Aβ metabolism early in the amyloidogenic process and provides a possible novel mechanism by which apoE affects AD pathogenesis
  • ScienceDirect ® is a registered trademark of Elsevier B.V

Need more features? Save interactive summary cards to your Scholarcy Library.