Folic Acid: Nutritional Biochemistry, Molecular Biology, and Role in Disease Processes

This paper reviews the chemistry, metabolism, and molecular biology of folic acid, with a particular emphasis on how it is, or may be, involved in many disease processes

Mark Lucock

2002

Scholarcy highlights

  • This paper reviews the chemistry, metabolism, and molecular biology of folic acid, with a particular emphasis on how it is, or may be, involved in many disease processes
  • The effect of folate in these conditions can be explained largely within the context of folate-dependent pathways leading to methionine and nucleotide biosynthesis, and genetic variability resulting from a number of common polymorphisms of folate-dependent enzymes involved in the homocysteine remethylation cycle
  • Allelic variants of folate genes that have a high frequency in the population, and that may play a role in disease formation include 677C → T-MTHFR, 1298A → C-MTHFR, 2756A → G-MetSyn, and 66A → G-MSR
  • Future work will probably uncover further polymorphisms of folate metabolism, and lead to a wider understanding of the interaction between this essential nutrient and the many genes which underpin its enzymatic utilization in a plethora of critical biosynthetic reactions, and which, under adverse nutritional conditions, may promote disease

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