Overexpression of Neutrophil Neuronal Nitric Oxide Synthase in Parkinson's Disease

We previously found a 50% increased ·NO production rate during the respiratory burst of circulating neutrophils from Parkinson's disease patients

Emilia M. Gatto; Natalia A. Riobó; M.Cecilia Carreras; Alejandra Cherñavsky; Andrea Rubio; M.Leonardo Satz; Juan J. Poderoso

2002

Scholarcy highlights

  • Much evidence supports a role of nitric oxide and peroxynitrite in experimental and idiopathic Parkinson's disease; an overexpression of neuronal nitric oxide synthase was recently reported in the basal ganglia of PD patients
  • We previously found a 50% increased ·NO production rate during the respiratory burst of circulating neutrophils from PD patients
  • PMN were isolated from blood samples obtained from seven PD patients and seven age- and sex-matched healthy donors; neuronal nitric oxide synthase mRNA was amplified by reverse transcriptase–polymerase chain reaction and the products were hybridized with a probe for nNOS
  • The results showed that both ·NO production and protein tyrosine nitration were significantly increased in PMN isolated from PD patients
  • It is likely that overexpression of neuronal nitric oxide synthase and formation of ONOO− in PMN cells from Parkinson's disease patients emphasizes a potential causal role of ·NO in the physiopathology of the illness

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