A Combined Pore Blockage and Cake Filtration Model for Protein Fouling during Microfiltration

The results provide important insights into the underlying mechanisms of protein fouling during microfiltration

Chia-Chi Ho

2002

Key concepts

Scholarcy highlights

  • Previous studies of protein fouling during microfiltration have shown significant discrepancies between filtrate flux data and predictions of the classical pore blockage, pore constriction, and cake filtration models
  • A new mathematical model was developed for the filtrate flux which accounts for initial fouling due to pore blockage and subsequent fouling due to the growth of a protein cake or deposit over these initially blocked regions
  • The model explicitly accounts for the inhomogeneity in the cake layer thickness over different regions of the membrane arising from the time-dependent blockage of the pore surface
  • The model was shown to be in excellent agreement with experimental data obtained during the stirred cell filtration of bovine serum albumin solutions through polycarbonate track-etched microfiltration membranes over the entire course of the filtration
  • The model provides a smooth transition from the pore blockage to cake filtration regimes, eliminating the need to use different mathematical formulations to describe these two phenomena
  • The results provide important insights into the underlying mechanisms of protein fouling during microfiltration

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