Ontogeny of B and T cells in sea bass (Dicentrarchus labrax, L.)

The results suggest that DLT15 recognises very early T cells as well as mature T cells and that these very early T cells might have their origin in a different compartment and subsequently mature in the thymus

Nuno M.S dos Santos; Nicla Romano; Maria de Sousa; Anthony E Ellis; Jan H.W.M Rombout

2002

Scholarcy highlights

  • Monoclonal antibodies specific to sea bass Ig heavy and light chains and T cells were used in an ontogenetic study of sea bass by flow cytometry and immunocytochemistry
  • B and T cell development was followed in samples of different offspring
  • The results suggest that DLT15 recognises very early T cells as well as mature T cells and that these very early T cells might have their origin in a different compartment and subsequently mature in the thymus
  • With the monoclonal antibodies used, adult levels of T and B cells were both reached between 137–145 dph, suggesting that sea bass is immunologically mature from at least that age onwards
  • The thymus appears to be the primary organ for T lymphocytes and head kidney the primary organ for B lymphocytes
  • Age seems to be more important in determining B cell maturation than body weight

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