A Novel Proanthocyanidin IH636 Grape Seed Extract Increases in Vivo Bcl-Xl Expression and Prevents Acetaminophen-Induced Programmed and Unprogrammed Cell Death in Mouse Liver

We identified potent antibacterial medicinal plants of Africa having other pharmacological activities such as anti-inflammatory, anticancer, anti-diabetic, central nervous system, cardiovascular, anti-parasitic, hepatoprotective, immunomodulatory, nephroprotective, reproduction and digestive systems, antiviral, and wound healing activities

Sidhartha D. Ray; M.Arun Kumar; D. Bagchi


Scholarcy highlights

  • Several molecular events in the apoptotic or necrotic death of hepatocytes induced by acetaminophen appear to be well defined
  • Results indicate that 7-day grape seed proanthocyanidin extract preexposure induced dramatic protection and markedly decreased liver injury and animal lethality culminated by AAP, when compared to a short-term 3-day exposure
  • Agarose gel electrophoresis revealed that 7-day GSPE preexposure prior to AAP administration completely blocked Ca2+/Mg2+-Ca2+/Mg2+-dependent-endonuclease-mediated ladder-like fragmentation of genomic DNA and significantly altered the bcl-Xl expression
  • These observations demonstrate that GSPE preexposure may significantly attenuate AAP-induced hepatic DNA damage, apoptotic and necrotic cell death of liver cells, and, most remarkably, antagonize the influence of AAP-induced changes in bcl-Xl expression in vivo
  • This study aimed to evaluate the effects of the dietary inclusion of grape seed, alone or in combination with linseed, on milk production traits, immune response, and liver and kidney metabolic activity of lactating ewes
  • COX-2 mRNA expression was reduced in animals treated with 1% red grape juice before AOM induction or 2% red grape juice after AOM induction
  • The highest regeneration capacity was observed in the dose of 5 mg L−1 AGP in MS of all the genotypes and hexaploid wheat Ikizce-96 gave the best results with the highest regeneration capacity and culture effects in the same dose of AGP. These results indicated that effective dose of AGP in regeneration medium increase plant regeneration in calli derived from cereal mature embryos

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