The endogenous cannabimimetic anandamide is hydrolyzed by a fatty acid amide hydrolase to yield arachidonic acid and ethanolamine
2002
Key concepts
Scholarcy highlights
- The endogenous cannabimimetic anandamide is hydrolyzed by a fatty acid amide hydrolase to yield arachidonic acid and ethanolamine
- The rate ofanandamide hydrolysis was found in both 7-week-old and 90-week-old rats to be in the order hippocampus > cerebral cortex > cerebellum > striatum ≈ midbrain, with higher rates of hydrolysis for the 7-week-old rats than for the 90-week-old rats
- Ketorolac inhibited rat brain anandamide hydrolysis, with IC50values of 50, 440, and 80 μM being found for the R, S, and R,S-forms, respectively
- The enantiomers of flurbiprofen and R-ketorolac are the most potent NSAID inhibitors of fatty acid amide hydrolase yet reported
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