Going even smaller: Engineering sub‐5 nm nanoparticles for improved delivery, biocompatibility, and functionality

The rapid development and advances in nanomaterials and nanotechnology in the past two decades have made profound impact in our approaches to individualized disease diagnosis and treatment

Manman Xie

2020

Key concepts

Scholarcy highlights

  • The rapid development and advances in nanomaterials and nanotechnology in the past two decades have made profound impact in our approaches to individualized disease diagnosis and treatment
  • Nanomaterials, mostly in the range of 10–200 nm, developed for biomedical applications provide a wide range of platforms for building and engineering functionalized structures, devices, or systems to fulfill the specific diagnostic and therapeutic needs
  • The emerging studies have provided new findings that demonstrated the unique size‐dependent physical properties, physiological behaviors and biological functions of the nanomaterials in the range of the sub‐5 nm scale, including renal clearance, novel imaging contrast, and tissue distribution. This advanced review attempts to introduce the new strategies of rational design for engineering nanoparticles with the core sizes under 5 nm in consideration of the clinical and translational requirements
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