Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR Project

In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record databases for large-scale monitoring of drug safety

Preciosa M. Coloma; Martijn J. Schuemie; Gianluca Trifirò; Rosa Gini; Ron Herings; Julia Hippisley-Cox; Giampiero Mazzaglia; Carlo Giaquinto; Giovanni Corrao; Lars Pedersen; Johan van der Lei; Miriam Sturkenboom; on behalf of the EU-ADR consortium

2010

Scholarcy highlights

  • In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record databases for large-scale monitoring of drug safety
  • The study population for this analysis comprised 19 647 445 individuals corresponding to 59 929 690 person-years of follow-up. 39 967 incident cases of UGIB were identified during the study period
  • NSAID use patterns were similar for databases within the same country but heterogeneous among different countries
  • A statistically significant age- and gender-adjusted association between use of any NSAID and increased risk for UGIB was confirmed in all databases, IRR from 2.0 to 4.3

Need more features? Save interactive summary cards to your Scholarcy Library.