Eight‐year weight losses with an intensive lifestyle intervention: The look AHEAD study

The present analyses focused on the first 8 years of intervention, which all participants had the opportunity to complete before the trial was halted in September 2012. Differences between the DSE and intensive lifestyle intervention groups in changes in weight over the 8 years were analyzed using a mixed effects analysis of covariance, which included baseline weight, clinical center, and treatment arm

The Look AHEAD Research Group

2013

Scholarcy highlights

  • The Look AHEAD study was designed to assess the effects of an intensive lifestyle intervention on clinically important health outcomes in overweight/obese individuals with type 2 diabetes
  • The trial’s primary outcome was cardiovascular morbidity and mortality, on which no significant differences were observed between participants assigned to ILI or a usual care group after a mean follow-up of 9.6 years
  • The present analyses focused on the first 8 years of intervention, which all participants had the opportunity to complete before the trial was halted in September 2012. Differences between the DSE and ILI groups in changes in weight over the 8 years were analyzed using a mixed effects analysis of covariance, which included baseline weight, clinical center, and treatment arm
  • At year 1, ILI participants lost a mean of 8.5% 6 0.2% of initial weight, compared with 0.6% 6 0.2% for DSE. As reported previously, more ILI than DSE participants lost 5% of initial weight, as well as 10%
  • Overweight/obese individuals with type 2 diabetes lost 4.7% of initial body weight at year 8, compared with 2.1% for participants assigned to DSE
  • Our primary hypotheses were that the ILI group, as compared with DSE, would achieve significantly greater mean weight losses at all years and be more successful in achieving reductions 5% and 10% of initial weight
  • The same statistical differences were observed between the ILI and DSE groups when including or censoring weight losses of participants who had bariatric surgery
  • Those who maintained the full 10% loss at year 8, compared with those who regained above baseline, reported greater practice of several weight-maintenance behaviors, including high levels of physical activity, reduced calorie intake, and frequent monitoring of body weight

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