Superoxide free radical spin‐lattice relaxivity: A quench‐assisted MR study

QuEnch-assiSTed MRI provides a unique biomarker of excessive production of paramagnetic free radicals in vivo

Martin J. MacKinnon; Bruce A. Berkowitz; Yen‐Yu Ian Shih

2021

Key concepts

Scholarcy highlights

  • QuEnch-assiSTed MRI provides a unique biomarker of excessive production of paramagnetic free radicals in vivo
  • Stable superoxide free radicals were generated in water phantoms of potassium superoxide (
  • The T1-weighted signal intensity increased with KO2 concentration
  • Superoxide r1 was measured to be 0.29 mM−1 s−1, in agreement with that reported for paramagnetic molecular oxygen and nitroxide free radicals
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