Soft Gelatin Capsules (Softgels)

The goal of the current review is to provide an in-depth discussion on the softgel dosage form to formulation scientists who are considering developing softgels for therapeutic compounds

Rampurna Prasad Gullapalli

2010

Scholarcy highlights

  • It is estimated that more than 40% of new chemical entities coming out of the current drug discovery process have poor biopharmaceutical properties, such as low aqueous solubility and/or permeability
  • Due to the very dynamic nature of the softgel dosage form, its development and stability during its shelf-life are fraught with several challenges
  • The goal of the current review is to provide an in-depth discussion on the softgel dosage form to formulation scientists who are considering developing softgels for therapeutic compounds
  • Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymphcannulated and non-cannulated rats

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