Synthesis, Characterization, and Cytotoxicity Evaluation of Some New Benzo[f ]coumarin Derivatives

Interaction of 2-(bromoacetyl)-3H-benzo coumarin with salicylaldehyde afforded 2-(2-oxo-2-(3H-benzo coumarin-2-yl)ethoxy)benzaldehyde which underwent self-condensation in refluxing dimethylformamide to afford 2-(2-benzofuroyl)-3H-benzo coumarin

Khaled S. Mohamed

2018

Scholarcy highlights

  • Interaction of 2-(bromoacetyl)-3H-benzocoumarin with salicylaldehyde afforded 2-(2-oxo-2-(3H-benzocoumarin-2-yl)ethoxy)benzaldehyde which underwent self-condensation in refluxing dimethylformamide to afford 2-(2-benzofuroyl)-3H-benzocoumarin
  • Refluxing of 5 in DMF led to formation of 2-(4H--benzothiazin-3-yl)-3H-benzocoumarin
  • Novel compounds bioactivity as antitumor were examined for in vitro cytotoxicity against HepG-2 and MCF-7

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