Critical review of Epstein–Barr virus microRNAs relation with EBV‐associated gastric cancer

Epstein–Barr virus -associated gastric cancer is regarded as the most prevalent malignant tumor triggered by EBV infection

Arghavan Zebardast; Sadra S. Tehrani; Tayebeh Latifi; Farzin Sadeghi

2021

Scholarcy highlights

  • Epstein–Barr virus-associated gastric cancer is regarded as the most prevalent malignant tumor triggered by EBV infection
  • These miRNAs implicated in immune evasion, identification of pattern recognition receptors, regulation of lymphocyte activation and lethality, modulation of infected host cell antigen, maintain of EBV infection status, promotion of cell proliferation, invasion and migration, and reduction of apoptosis
  • Has recent data demonstrated the crucial function of EBV-encoded miRNAs in the pathogenesis of EBVaGC, but it has been revealed that aberrant expression of exosomal miRNAs in EBVaGC has made them biomarkers for detection of EBVaGC
  • The critical role of EBV-encoded miRNAs has been a hot topic in research
  • We will focus on the multiple mechanisms involved in EBVaGC caused by EBV-encoded miRNAs and briefly discuss their potential application in the clinic as a diagnostic biomarker

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