Key genes and functional coexpression modules involved in the pathogenesis of systemic lupus erythematosus

This study identifies a number of key genes and functional coexpression modules involved in systemic lupus erythematosus, which provides deepening insights into the molecular mechanism of SLE at a systems level and provides some promising therapeutic targets

Shushan Yan

2018

Scholarcy highlights

  • We performed a systematic review of genome-wide gene expression datasets to identify key genes and functional modules involved in the pathogenesis of systemic lupus erythematosus at a systems level
  • Genome-wide gene expression datasets involving SLE patients were searched in Gene Expression Omnibus and ArrayExpress databases
  • Robust rank aggregation analysis was used to integrate those public datasets and identify key genes associated with SLE
  • The weighted gene coexpression network analysis was adapted to identify functional modules involved in SLE pathogenesis, and the gene ontology enrichment analysis was utilized to explore their functions
  • This study identifies a number of key genes and functional coexpression modules involved in SLE, which provides deepening insights into the molecular mechanism of SLE at a systems level and provides some promising therapeutic targets
  • Any queries should be directed to the corresponding author for the article

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