Co-translational trimerization of the reovirus cell attachment protein.

We investigated the temporality and ATP requirement of this trimerization event in the context of sigma1 biogenesis

R. Gilmore


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  • Recent findings indicate that the N‐terminal fibrous tail and the C‐terminal globular head each possess a distinct trimerization domain
  • Our data suggest that assembly of nascent sigma chains at the N‐terminus is intrinsically ATP independent, and occurs co‐translationally when the ribosomes have traversed past the midpoint of the mRNA

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