Brain mitochondrial dysfunction in aging

Mitochondria were brought to attention in aging biology due to the central role of mitochondria in producing chemical energy to meet cellular requirements and to the declines of basal metabolic rate and of physiological performances which are characteristic of aged mammals

Alberto Boveris

2008

Scholarcy highlights

  • Mitochondria were brought to attention in aging biology due to the central role of mitochondria in producing chemical energy to meet cellular requirements and to the declines of basal metabolic rate and of physiological performances which are characteristic of aged mammals
  • Dysfunctional mitochondria by mitochondria-dependent apoptosis drive the brain to a physiological deficit
  • Aged brain mitochondria show an increased content of oxidation products, an observation that puzzled researchers considering that mitochondria have a much faster turnover than neurons
  • The hypothesis is that aged neurons loose the capacity to synthesize mtNOS with a decrease in the NO diffusion to the cytosol and in NO-mediated mitochondrial biogenesis
  • A mitochondrial high energy charge is characterized by high rates of NO and H2O2 diffusion to the cytosol
  • With a 30% reduction in complex I activity can increase ATP production by 1.9 times by switching mitochondria from state 4 to state 3
  • The study of mitochondrial NO and H2O2 diffusion to the cytosol as a function of age will contribute to the understanding of mitochondrial biogenesis, cell proliferation and apoptosis in aging, a process that leads to cellular energy deficits and tissue atrophy

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